Anti-Phospho-FADD( S194) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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FADD
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R09-6S-3
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
-
-
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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8772
Uniprot ID
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Q13158
Background
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The protein is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade.
Research Area
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Cell Biology
Synonyms
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Growth-inhibiting gene 3 protein；Mediator of receptor induced toxicity