Anti-Phospho-DLC1 (Ser986) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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DLC1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Synthetic peptide of human DLC1
Molecular Weight
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Calculated MW: 171 kDa; Observed MW: 171,114,123 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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10395
Uniprot ID
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Q96QB1
Background
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Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.
Research Area
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Tags & Cell Markers
Synonyms
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ARHGAP7; KIAA1723; STARD12; Rho GTPase-activating protein 7