Anti-Phospho-CRK (Tyr221) Rabbit Monoclonal Antibody

Anti-Phospho-CRK (Tyr221) Rabbit Monoclonal Antibody
Anti-Phospho-CRK (Tyr221) Rabbit Monoclonal Antibody

Anti-Phospho-CRK (Tyr221) Rabbit Monoclonal Antibody

Rabbit IgG Monoclonal for CRK detection, Test with WB, ICC/IF in Human

Reactivity
  • Human
Application
  • WB
  • ICC
  • IF
Host
  • Rabbit
Catalog Number
    ABXB63988
$370.00

Shipping To:
United States

Product Information

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Target
    CRK
Host
  • Rabbit
Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
  • Monoclonal
Clone Number
    R04-6L8
Isotype
    IgG
Reactivity
  • Human
Application
  • WB
  • ICC
  • IF
Application Details
    WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
    A synthesized peptide derived from human Phospho-CrkII (Tyr221)
Molecular Weight
    Calculated MW: 34 kDa; Observed MW: 42 kDa
Formulation
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
    Liquid
Gene ID
    1398
Uniprot ID
    P46108
Background
    The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk-II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
Research Area
    Cell Biology
Synonyms
    Adapter molecule crk; avian sarcoma virus CT10 (v-crk) oncogene homolog; CRK; CRKII; Proto-oncogene c-Crk
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Product Image

Western blot analysis of Phospho-CrkII (Tyr221) in (1) K562 lysates treated with AP; (2) K562 lysates using Phospho-CRK (Tyr221) antibody.