Anti-Phospho-Chk2 (Thr68) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
CHEK2
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R23-2L-9
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IP: 1/50
Immunogen
-
A synthesized peptide derived from human Phospho-Chk2 (T68)
Molecular Weight
-
Calculated MW: 61 kDa;Observed MW:65kDa
Formulation
-
Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
-
Liquid
Gene ID
-
11200
Uniprot ID
-
O96017
Background
-
These are known to be preferred sites for phosphorylation by ATM/ATR kinases. After DNA damage by ionizing radiation (IR), UV irradiation, or hydroxyurea treatment, Thr68 and other sites in this region become phosphorylated by ATM/ATR. The SQ/TQ cluster domain, therefore, seems to have a regulatory function.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
CHEK2; CHK2; Cds1; Chk2; EC 2.7.11.1; RAD53; kinase Chk2;