Anti-Phospho-c-Fos (Ser362) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
FOS
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000 IHC: 1/50-1/200
Immunogen
-
Synthetic phosphopeptide derived from human c-Fos around the phosphorylation site of Serine 362.
Molecular Weight
-
-
Formulation
-
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
-
Liquid
Gene ID
-
2353
Uniprot ID
-
P01100
Background
-
The c-Fos oncogene was initially detected in two independent murine osteosarcoma virus isolates and an avian nephroblastoma virus. The cellular homolog, c-Fos, encodes a nuclear phospho-protein that is rapidly and transiently induced by a variety of agents and functions as a transcriptional regulator for several genes. In contrast to c-Jun proteins, which form homo- and heterodimers which bind to specific DNA response elements, c-Fos proteins are only active as heterodimers with members of the Jun gene family. Functional homologs of c-Fos include the Fra-1, Fra-2 and Fos B genes. In addition, selected ATF/CREB family members can form leucine zipper dimers with Fos and Jun. Different dimers exhibit differential specificity and affinity for AP-1 and CRE sites.
Research Area
-
-
Synonyms
-
Proto-oncogene c-Fos; Cellular oncogene fos; G0/G1 switch regulatory protein 7; FOS; G0S7