Anti-Phospho-alpha Synuclein (Tyr136) Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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SNCA
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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Peptide sequence around phosphorylation site of tyrosine 136 (Q-D-Y(p)-E-P) derived from Human α-Synuclein.
Molecular Weight
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Calculated MW: 14 kDa; Observed MW: 18 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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6622
Uniprot ID
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P37840
Background
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May be involved in the regulation of dopamine release and transport. Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. Genetic alterations of SNCA resulting in aberrant polymerization into fibrils, are associated with several neurodegenerative diseases (synucleinopathies).
Research Area
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Neuroscience
Synonyms
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SNCA; NACP; PARK1; Alpha-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP