Anti-PHF3 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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PHF3
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
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Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/200
Immunogen
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Synthetic peptide corresponding to the C-terminus of Human PHF3.
Molecular Weight
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Calculated MW: 229kDa
Formulation
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1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
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Liquid
Gene ID
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23469
Uniprot ID
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Q92576
Background
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PHF3 (PHD finger protein 3) is a 2039 amino acid ubiquitously expressed protein that is phosphorylated upon DNA damage by either ATM or ATR. PHF3 contains a PHD finger motif, a proline-rich region, a TFIIS domain and two bipartite nuclear localization signals. Since these motifs are frequently found in proteins involved in transcription, PHF3 may function as a transcription factor. Expression of PHF3 is significantly reduced in anaplastic astrocytomas, glioblastomas and glioblastoma cell lines, suggesting that PHF3 plays a role as a tumor suppressor. Antibodies against PHF3 are present in some patients afflicted with glioblastoma multiforme and presence of the , correlates to significantly better survival rates. There are two isoforms of PHF3 that are produced as a result of alternative splicing events.
Research Area
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Synonyms
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PHD finger protein 3; PHF3; PHF3;