Anti-PEG10 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
PEG10
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R02-7H-5
Isotype
-
IgG
Reactivity
Application
Application Details
-
IHC: 1/100-1/200
Immunogen
-
Recombinant protein of human PEG10
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
23089
Uniprot ID
-
Q86TG7
Background
-
PEG10, paternally expressed 10. The PEG10 includes two overlapping reading frames of the same transcript encoding distinct isoforms. The shorter isoform has a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons, and it functions in part by interacting with members of the TGF-beta receptor family. The longer isoform has the active-site DSG consensus sequence of the protease domain of pol proteins. The longer isoform is the result of -1 translational frameshifting that is also seen in some retroviruses. Expression of these two isoforms only comes from the paternal allele due to imprinting. Increased gene expression (as observed by an increase in mRNA levels) is associated with hepatocellular carcinomas.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
Edr; HB-1; Mar2; MEF3L; Mart2; RGAG3