Anti-PDCD4 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
PDCD4
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
9T7-M7-I9
Isotype
-
IgG1/kappa
Reactivity
Application
Application Details
-
WB：1/500-1/1000，IHC-P：1/50-1/100，ICC/IF：1/50
Immunogen
-
Peptide
Molecular Weight
-
Calculated MW: 52 kDa; Observed MW:56 kDa
Formulation
-
Liquid in PBS, Glycerol and BSA
Form
-
Liquid
Gene ID
-
27250
Uniprot ID
-
Q53EL6
Background
-
PDCD4 was a suppressor of neoplastic transformation. It interacts with eukaryotic initiation factors eIF4AI and eIF4AII. PDCD4 colocalizes with eIF4A in the cytoplasm and inhibits the activity of eIF4A as an ATP-dependent RNA helicase. PDCD4 inhibits cap-dependent translation. Upon stimulation by mitogens, PDCD4 is phosphorylated on Ser67 by S6K1 kinase and then degraded through the ubiquitin pathway leading to enhanced translation and cell growth.
Research Area
-
Cell Biology
Synonyms
-
Protein 197/15a, H731