Anti-PD2R Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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PTGDR
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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Synthetic peptide corresponding to Human PD2R.
Molecular Weight
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Calculated MW: 40kDa
Formulation
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1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
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Liquid
Gene ID
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5729
Uniprot ID
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Q13258
Background
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The prostaglandin D2 receptor is a member of the G-protein-coupled receptor (GPCR) family (subfamily: prostanoid). It has been shown to function as a prostanoid DP receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. Prostaglandin D2 receptor has been reported to be expressed in human small intestine, colon (goblet cells), eye, and eosinophils. ESTs have been isolated from human brain libraries.
Research Area
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Synonyms
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Prostaglandin D2 receptor; PGD receptor; PGD2 receptor; Prostanoid DP receptor; PTGDR