Anti-PAG1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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PAG1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R02-4H6
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 IP: 1/50 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human PAG
Molecular Weight
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Calculated MW: 47 kDa; Observed MW: 80 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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55824
Uniprot ID
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Q9NWQ8
Background
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Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells and FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Promotes CSK activation and recruitment to lipid rafts, which results in LCK inhibition. Inhibits immunological synapse formation by preventing dynamic arrangement of lipid raft proteins.
Research Area
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Cell Biology
Synonyms
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CBP; Csk binding protein; PAG; PAG1