Anti-Osteoprotegerin Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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TNFRSF11B
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R38-6D-4
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/100-1/200 IF: 1/50-1/200
Immunogen
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A synthesized peptide derived from human Osteoprotegerin
Molecular Weight
-
-
Formulation
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Liquid in PBS , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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4982
Uniprot ID
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O00300
Background
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Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis.
Research Area
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Cardiovascular
Synonyms
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OCIF; OPG; Osteoclastogenesis inhibitory factor; Osteoprotegerin; PDB5; TNFRSF11B; TR1;