Anti-NUMB Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
NUMB
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R08-5B6
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000
Immunogen
-
A synthesized peptide derived from human NUMB
Molecular Weight
-
Calculated MW: 71 kDa; Observed MW: 71 kDa
Formulation
-
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
-
Liquid
Gene ID
-
8650
Uniprot ID
-
P49757
Background
-
Numb acts as a negative regulator of Notch signaling by promoting ubiquitination and degradation of Notch. The protein is asymmetrically segregated into one daughter cell during cell division, producing two daughter cells with different responses to Notch signaling and different cell fates. The localization of Numb can also be regulated by G-protein coupled receptor (GPCR) and PKC signaling.
Research Area
-
Neuroscience
Synonyms
-
NUMB; Protein numb homolog; h-Numb; Protein S171