Anti-Notch4 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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NOTCH4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-8H5
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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A synthetic peptide of human NOTCH4
Molecular Weight
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Calculated MW: 210 kDa; Observed MW: 36 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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4855
Uniprot ID
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Q99466
Background
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Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May regulate branching morphogenesis in the developing vascular system (By similarity).
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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NOTCH4; INT3; Neurogenic locus notch homolog protein 4; Notch 4; hNotch4