Anti-NMDAR2A Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Grin2A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R03-2K3
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Recombinant protein of mouse NMDAR2A
Molecular Weight
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Calculated MW: 165 kDa; Observed MW: 165 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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14811
Uniprot ID
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P35436
Background
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Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg2+. Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B . Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning.
Research Area
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Neuroscience
Synonyms
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NR2A; GluN2A; NMDAR2A; GluRepsilon1