Anti-Nicastrin Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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NCSTN
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R02-8L5
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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A synthesized peptide derived from human Nicastrin
Molecular Weight
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Calculated MW: 78 kDa; Observed MW: 120,140 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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23385
Uniprot ID
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Q92542
Background
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Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex.
Research Area
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Neuroscience
Synonyms
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APH2; Ncstn; NCT; Nicastrin