Anti-Neurofilament Light Polypeptide Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
NEFL
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
2D7-6C10-10B2
Isotype
-
IgG2b
Reactivity
Application
Application Details
-
IHC: 1/100-1/500
Immunogen
-
Synthesized peptide derived from human Neurofilament
Molecular Weight
-
-
Formulation
-
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
-
Liquid
Gene ID
-
4747
Uniprot ID
-
P07196
Background
-
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Research Area
-
Neuroscience
Synonyms
-
NEFL; NF68; NFL; Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein