Anti-NEFL Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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NEFL
Host
Storage
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Store at -20°C to -80°C for 12 months in lyophilized form.
Clonality
Clone Number
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R09-2Q-9
Isotype
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IgG
Reactivity
Application
Application Details
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FC: 1/50-1/100 ELISA: 1/10000
Immunogen
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Recombinant human NEFL protein
Molecular Weight
-
-
Formulation
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Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Form
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Lyophilized
Gene ID
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4747
Uniprot ID
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P07196
Background
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Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.
Research Area
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Neuroscience
Synonyms
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NEFL; NF68; NFL; Neurofilament light polypeptide; NF-L; 68 kDa neurofilament protein; Neurofilament triplet L protein