Anti-Nectin 2 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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NECTIN2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R03-9M-7
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/100-1/200
Immunogen
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Recombinant protein of human Nectin 2
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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5819
Uniprot ID
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Q92692
Background
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Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive (PubMed:26755705).
Research Area
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Immunology
Synonyms
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NECTIN2;HVEB, PRR2, PVRL2;CD112;Nectin-2;Herpes virus entry mediator B (Herpesvirus entry mediator B; HveB);Nectin cell adhesion molecule 2;Poliovirus receptor-related protein 2