Anti-Myotubularin Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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MTM1
Host
Storage
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Store at 2-8°C for up to 2 weeks. store at -20°C for long term storage in small aliquots. Avoid freeze/thaw cycles.
Clonality
Clone Number
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Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/2000
Immunogen
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This DANRE mtm1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide from the region of DANRE mtm1.
Molecular Weight
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Calculated MW:74 kDa; Observed MW: 74 kDa
Formulation
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Liquid in PBS containing 0.09% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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560881
Uniprot ID
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Q32PM3
Background
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Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) . Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome . Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture . Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels.
Research Area
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Synonyms
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Myotubularin，Phosphatidylinositol-3,5-bisphosphate 3-phosphatase，Phosphatidylinositol-3-phosphate phosphatase，mtm1