Anti-Munc 13-4 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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UNC13D
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R07-3X-1
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 FC: 1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW:123 kDa;Observed MW: 123 kDa
Formulation
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Liquid in 50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Form
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Liquid
Gene ID
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201294
Uniprot ID
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Q70J99
Background
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Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.
Research Area
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Immunology
Synonyms
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Munc13-4,Protein unc-13 homolog D