Anti-MTSS1 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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MTSS1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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IHC: 1/50-1/100
Immunogen
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Synthetic peptide of human MTSS1
Molecular Weight
-
-
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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9788
Uniprot ID
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O43312
Background
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MTSS1 (metastasis suppressor 1), also known as MIM, MIMA or MIMB, is a 755 amino acid protein that contains one Actin-binding WH2 (Wiskott-Aldrich syndrome protein homology-2) domain and one IMD domain. Expressed in a variety of tissues including Tis, thymus, prostate, spleen, colon, uterus and blood, MTSS1 is thought to bind to Actin and, via this binding, may affect the dynamics of the cytoskeleton. Through its association with the cytoskeleton, MTSS1 plays a role in controlling the progression and metastasis of carcinomas in various organ sites throughout the body and, when expressed at normal levels, functions as a tumor suppressor. Overexpression of MTSS1 results in the formation of abnormal actin structures, an event that may lead to tumorigenesis. Three isoforms of MTSS1 exist due to alternative splicing events.
Research Area
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Signal Transduction
Synonyms
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MIM; MIMA; MIMB