Anti-MonoMethyl-Histone H3 (Lys23) Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
H3C1
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R09-5C-2
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB：1/500-1/1000 IHC-P：1/50-1/100
Immunogen
-
Peptide
Molecular Weight
-
-
Formulation
-
Liquid in PBS, Glycerol and BSA
Form
-
Liquid
Gene ID
-
8350
Uniprot ID
-
P68431
Background
-
Histone post-translational modifications (PTMs) are key mechanisms of epigenetics that modulate chromatin structures, termed as “histone code”. The PTMs on histone including acetylation, methylation, phosphorylation and novel acylations directly affect the accessibility of chromatin to transcription factors and other epigenetic regulators, altering genome stability, gene transcription, etc. Histone methylation occurs primarily at lysine and arginine residues on the amino terminal of core histones. Methylation of histones can either increase or decrease transcription of genes, depending on which amino acids (Lys or Arg) in the histones are methylated and how many methyl groups are attached (mono-, di-, tri-methylation on Lys, mono-di-symmetric/asymmetric methylation on Arg). Mostly, lysine methylation occurs primarily on histone H3 Lys4, 9, 27, 36, 79 and H4 Lys20, while Arginine methylation occurs primarily on histone H3 Arg2, 8, 17, 26 and H4 Arg3. Histone methylases (HMTs) and histone demethylases (HDMs) are major regulating factors.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
H3K23me; Histone H3/b；Histone H3/c；Histone H3/d；Histone H3/f