Anti-MMP7 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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MMP7
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Fusion protein of human MMP7
Molecular Weight
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Calculated MW: 30 kDa; Observed MW: 30 kDa
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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4316
Uniprot ID
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P09237
Background
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in inTinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Research Area
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Cardiovascular
Synonyms
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MMP-7; MPSL1; PUMP-1