Anti-MGMT Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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MGMT
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Fusion protein of human MGMT
Molecular Weight
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Calculated MW: 22 kDa; Observed MW: 22 kDa
Formulation
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pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
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Liquid
Gene ID
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4255
Uniprot ID
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P16455
Background
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MGMT (O-6-methylguanine-DNA methyltransferase) is a DNA repair enzyme that participates in a suicide reaction that specifically removes methyl or alkyl groups from the O(6) position of guanine, restoring guanine to its normal form without causing DNA breaks. MGMT protects cells from alkylating toxins, and is an important factor in drug resistance to alkylating therapeutic agents.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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Methylated-DNA--protein-cysteine methyltransferase