Anti-Melatonin Receptor 1A Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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MTNR1A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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IF: 1/50-1/200 ELISA: 1/10000
Immunogen
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synthesized peptide of human MTR1A.
Molecular Weight
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-
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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4543
Uniprot ID
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P48039
Background
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This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Research Area
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Neuroscience
Synonyms
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MTNR1A; Melatonin receptor type 1A; Mel-1A-R; Mel1a receptor