Anti-MEK1(E203K Mutant) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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MAP2K1, MAPKK1, MEK1, MKK1, PRKMK1
Host
Storage
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Store at -20°C. Avoid repeated freezing and thawing
Clonality
Clone Number
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9E3-N3-A9
Isotype
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IgG
Reactivity
Application
Application Details
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ELISA: 1/1000-1/5000 WB: 1/500-1/1000
Immunogen
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A synthetic peptide from the internal region of MEK1 which includes the mutation of E203K, human origin.
Formulation
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PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
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Liquid
Uniprot ID
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Background
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MEK1 (also known as extracellular signal-regulated kinases, ERKs) plays important role in the MAP kinase cascade, which transduces multiple extracellular signals to control cell growth, proliferation and differentiation. Activated upon growth factors stimulation, MEK1 phosphorylates MAPK3/ERK1 and MAPK1/ERK2, thus activates the MAP pathway and regulates transcription. Abnormal of the MEK1 protein, including point mutations, are implicated in diseases such as cardiofaciocutaneous syndrome (CFC) and melanoma.
Research Area
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Signal Transduction
Synonyms
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MAP2K1, MAPKK1, MEK1, MKK1, PRKMK1