Anti-MCM7 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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MCM7
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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1H6-B7-M2
Isotype
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IgG1/kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 81 kDa; Observed MW:85 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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4176
Uniprot ID
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P33993
Background
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MCM7 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM7 proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of MCM7 and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of MCM7 with the tumor suppressor protein RB1/RB.
Research Area
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Cell Biology
Synonyms
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CDC47 homolog, P1.1-MCM3, CDC47, MCM2