Anti-MCM3 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
MCM3
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R09-4J-1
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB：1/500-1/1000 IHC-P：1/50-1/100
Immunogen
-
Peptide
Molecular Weight
-
Calculated MW: 91 kDa; Observed MW:100 kDa
Formulation
-
Liquid in PBS, Glycerol and BSA
Form
-
Liquid
Gene ID
-
4172
Uniprot ID
-
P25205
Background
-
Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for DNA replication and cell proliferation.
Research Area
-
Cell Biology
Synonyms
-
P1-MCM3, RLF subunit beta, p102