Anti-M-CSF Receptor Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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Csf1R
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R06-5H8
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Recombinant protein of mouse MCSF Receptor
Molecular Weight
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Calculated MW: 109 kDa; Observed MW: 109 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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12978
Uniprot ID
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P09581
Background
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Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.
Research Area
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Cardiovascular
Synonyms
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M-CSF Receptor; CSF-1-R; CSF-1R; M-CSF-R; Proto-oncogene c-Fms; CD115