Anti-LSM12 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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LSM12
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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8S6-Y2-K8
Isotype
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IgG2a/kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 21 kDa; Observed MW:21 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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124801
Uniprot ID
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Q3MHD2
Background
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In molecular biology, LSm proteins are a family of RNA-binding proteins found in virtually every cellular organism. LSm is a contraction of 'like Sm', because the first identified members of the LSm protein family were the Sm proteins. LSm proteins are defined by a characteristic three-dimensional structure and their assembly into rings of six or seven individual LSm protein molecules, and play a large number of various roles in mRNA processing and regulation. The Sm proteins were first discovered as antigens targeted by so-called anti-Sm antibodies in a patient with a form of systemic lupus erythematosus (SLE), a debilitating autoimmune disease. They were named Sm proteins in honor of Stephanie Smith, a patient who suffered from SLE. Other proteins with very similar structures were subsequently discovered and named LSm proteins. The LSm12 proteins have been described very recently. It is two-domain proteins with a N-terminal LSm domain and a C-terminal methyl transferase domain. There is some evidence that LSm12 is possibly involved in mRNA degradation. Unexpectedly, LSm12 was recently implicated in Calcium signaling by acting as the intermediate binding-protein for the nucleotide second messenger.
Research Area
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Cell Biology
Synonyms
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Protein LSM12 homolog