Anti-LOX1 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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OLR1
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R09-1S-8
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000，ICC/IF：1/50，FC：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 31 kDa; Observed MW:55 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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4973
Uniprot ID
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P78380
Background
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This protein is a low density lipoprotein receptor that belongs to the C-type lectin superfamily. It is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants. Diseases associated with OLR1 include Myocardial Infarction and Chlamydia Pneumonia. Among its related pathways are Innate Immune System and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include carbohydrate binding and low-density lipoprotein particle receptor activity.
Research Area
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Cell Biology
Synonyms
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OLR1, CLEC8A