Anti-LONP2 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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LONP2
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Clonality
Clone Number
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Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Synthetic peptide corresponding to Human LONP2
Molecular Weight
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Calculated MW: 96kDa
Formulation
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1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Form
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Liquid
Gene ID
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83752
Uniprot ID
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Q86WA8
Background
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LONP2 (lon peptidase 2, peroxisomal), also known as LONP, LONPL or peroxisomal lon protease, is an 852 amino acid protein belonging to the peptidase S16 family. LONP2 assists in import of peroxisomal matrix proteins and is required for PTS2 (type 2 peroxisome targeting signal)-containing protein processing. As an ATP-dependent serine protease, LONP2 plays a role in degradation of polypeptides that are unassembled or incorrectly folded. The gene encoding LONP2 maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn’s disease, which is a gastrointestinal inflammatory condition.
Research Area
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Synonyms
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Lon protease homolog 2, peroxisomal; Lon protease-like protein 2; Lon protease 2; Peroxisomal Lon protease; LONP2; LONP