Anti-LIN28A (2C1) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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LIN28A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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2C1-F9-A2
Isotype
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IgG2a
Reactivity
Application
Application Details
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WB: 1/500-1/1000
Immunogen
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Purified recombinant human LIN28A protein fragments expressed in E.coli
Molecular Weight
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Calculated MW: 23 kDa; Observed MW: 26 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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79727
Uniprot ID
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Q9H9Z2
Background
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Involved in the timing of developmental events and choice of stage specific cell fates. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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CSDD1; FLJ12457; LIN 28; Lin-28A; LIN28; LIN28A; LN28A_HUMAN; Protein lin-28 homolog A; ZCCHC1; Zinc finger CCHC domain-containing protein 1.