Anti-Leptin (5C11) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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LEP
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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5C11-G6-B12
Isotype
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IgG2a
Reactivity
Application
Application Details
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ELISA: 1/10000
Immunogen
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Purified recombinant full length of human Leptin protein expressed in E.coli.
Molecular Weight
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-
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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3952
Uniprot ID
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P41159
Background
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This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
Research Area
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Signal Transduction
Synonyms
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OB; OBS; LEPD; LEP