Anti-LC3B Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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MAP1LC3B
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R09-1Q-7
Isotype
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IgG/kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 14 kDa; Observed MW:14,16 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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81631
Uniprot ID
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Q9GZQ8
Background
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Microtubule-associated proteins 1A/1B light chain 3B (hereafter referred to as LC3B ) is a protein that is encoded by the MAP1LC3B gene in human. LC3B is a central protein in the autophagy pathway where it functions in autophagy substrate selection and autophagosome biogenesis. LC3B is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. Newly synthesized LC3's C-terminus is hydrolyzed by a cysteine protease called ATG4B exposing Gly120, termed LC3-I. LC3-I, through a series of ubiquitin-like reactions involving enzymes ATG7, ATG3, and ATG12-ATG5-ATG16, becomes conjugated to the head group of the lipid phosphatidylethanolamine. The lipid modified form of LC3, referred to as LC3-II, is believed to be involved in autophagosome membrane expansion and fusion events.
Research Area
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Signal Transduction
Synonyms
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MAP1A/MAP1B LC3B, MAP1LC3B, MAP1ALC3