Anti-Laminin alpha 5 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
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LAMA5
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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-
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/10000
Immunogen
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The antiserum was produced against synthesized peptide derived from human LAMA5.
Molecular Weight
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Calculated MW: 400 kDa; Observed MW: 400 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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3911
Uniprot ID
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O15230
Background
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Components of the extracellular matrix exert myriad effects on tissues throughout the body. In particular, the laminins, a family of heterotrimeric extracellular glycoproteins, affect tissue development and integrity in such diverse organs as the kidney, lung, skin, and nervous system. It is thought that laminins mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins function as heterotrimeric complexes of alpha, beta, and gamma chains, with each chain type representing a different subfamily of proteins. The protein encoded by this gene belongs to the alpha subfamily of laminin chains and is a major component of basement membranes. Two transcript variants encoding different isoforms have been found for this gene, but the full-length nature of one of them has not been determined.
Research Area
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Signal Transduction
Synonyms
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Laminin-10 subunit alpha; Laminin-11 subunit alpha; Laminin-15 subunit alpha