Anti-Lamin A/C Rabbit Monoclonal Antibody

Anti-Lamin A/C Rabbit Monoclonal Antibody
Anti-Lamin A/C Rabbit Monoclonal Antibody
Anti-Lamin A/C Rabbit Monoclonal Antibody
Anti-Lamin A/C Rabbit Monoclonal Antibody
Anti-Lamin A/C Rabbit Monoclonal Antibody
Anti-Lamin A/C Rabbit Monoclonal Antibody
Anti-Lamin A/C Rabbit Monoclonal Antibody
Anti-Lamin A/C Rabbit Monoclonal Antibody

Anti-Lamin A/C Rabbit Monoclonal Antibody

Rabbit IgG Monoclonal for LMNA detection, Test with WB, IHC-F, IHC-P, ICC/IF in Human, Mouse

Reactivity
  • Human
  • Mouse
Application
  • WB
  • IHC-F
  • IHC-P
  • ICC
  • IF
Host
  • Rabbit
Catalog Number
    ABXB62017
$370.00

Shipping To:
United States

Product Information

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Target
    LMNA
Host
  • Rabbit
Storage
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
  • Monoclonal
Clone Number
    R07-1I5
Isotype
    IgG
Reactivity
  • Human
  • Mouse
Application
  • WB
  • IHC-F
  • IHC-P
  • ICC
  • IF
Application Details
    WB: 1/500-1/1000 IHC: 1/50-1/100 IF: 1/50-1/200
Immunogen
    A synthetic peptide of human Lamin A/C
Molecular Weight
    Calculated MW: 74 kDa; Observed MW: 74,63 kDa
Formulation
    50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
    Liquid
Gene ID
    4000
Uniprot ID
    P02545
Background
    Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.
    Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Research Area
    Tags & Cell Markers
Synonyms
    LMNA; LMN1; Prelamin-A/C
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Product Image

Immunocytochemistry analysis of Lamin A/C (green) in Hela using Lamin A/C antibody,and DAPI(blue).
Western blot analysis of Lamin A/C in 3T3, C2C12 lysates using Lamin A/C antibody.
Western blot analysis of Lamin A/C in U251, Lncap, A549 lysates using Lamin A/C antibody
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A/C antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.