Anti-Lamin A/C (5D12) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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LMNA
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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5D12-C6-E9
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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Purified recombinant human LMNA protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 74 kDa; Observed MW: 63,74 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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4000
Uniprot ID
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P02545
Background
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Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics.
Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Research Area
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Tags & Cell Markers
Synonyms
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LMNA; LMN1; Prelamin-A/C