Anti-KMT6 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
-
EZH2
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
R08-5C6
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000
Immunogen
-
Recombinant protein of human KMT6/EZH2
Molecular Weight
-
Calculated MW: 85 kDa; Observed MW: 98 kDa
Formulation
-
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
-
Liquid
Gene ID
-
2146
Uniprot ID
-
Q15910
Background
-
Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Compared to EZH2-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
WVS; ENX1; KMT6; WVS2; ENX-1; EZH2b; KMT6A; EZH2