Anti-Keratin 20 Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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KRT20
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-8V-8
Isotype
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IgG
Reactivity
Application
Application Details
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WB：1/500-1/1000，IHC-P：1/50-1/100，ICC/IF：1/50，FC：1/50-1/100
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 48 kDa; Observed MW:48 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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54474
Uniprot ID
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P35900
Background
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Keratin (cytokeratin) is an intermediate filament protein, which is mainly expressed in epithelial cells such as gastric epithelium and intestinal epithelium. Keratin heterodimers composed of acidic keratin (or type I keratin, keratin 9 to 23) and basic keratin (or type II keratin, keratin 1 to 8) assemble to form filaments. Keratin isoforms exhibit tissue- and differentiation-specific characteristics, making them useful as research biomarkers. Studies have shown that mutations in the keratin gene are related to skin diseases, liver and pancreatic diseases, and inflammatory bowel disease. Therefore, cytokeratin can be used as a tumor immunohistochemical marker.Keratin 20 (CK-20) is an essential intermediate filament component and the main cytoskeleton keratin of the intestinal epithelium. Studies have shown that keratin 20 is an important marker for colon cancer, liver cancer, and stomach cancer.
Research Area
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Cell Biology
Synonyms
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CK-20, KRT20, Cytokeratin-20