Anti-KDM5C/JARID1C/SmcX Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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KDM5C
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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8Y7-L7-H8
Isotype
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IgG2a/kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 176 kDa; Observed MW:176 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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8242
Uniprot ID
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P41229
Background
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SMCX, as named KDM5C, belongs to the ARID protein family that harbors conserved DNA-binding motifs and acts as a histone H3 lysine 4 demethylase, suggesting a potential role in epigenetic regulation during development, cell differentiation. KDM5C protein is homologous to three other proteins of the human JARID1 family (JARID1A, JARID1B and JARID1C). This family shares several evolutionarily conserved domains, including the catalytic JmjC domain, JmjN domain, Arid/Bright domain, C5HC2 zinc-finger domain and two plant homeodomains (PHD), a motif that binds methyl-lysine residues.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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Lysine-specific demethylase 5C, Histone demethylase JARID1C, KDM5C