Anti-KDM1B Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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KDM1B
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R08-5J5
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/60 FC: 1/50-1/100
Immunogen
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A synthesized peptide derived from human LSD2 / AOF1
Molecular Weight
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Calculated MW: 92 kDa; Observed MW: 92 kDa
Formulation
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Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form
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Liquid
Gene ID
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221656
Uniprot ID
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Q8NB78
Background
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Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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AOF1; KDM1B; LSD2; Lysine-specific histone demethylase 1B; Lysine-specific histone demethylase 2