Anti-KDM1A (1E5) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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KDM1A
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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1E5-H2
Isotype
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IgG1
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200 IP: 1/20
Immunogen
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Purified recombinant human KDM1/LSD1 protein fragments expressed in E.coli.
Molecular Weight
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Calculated MW: 93 kDa; Observed MW: 110 kDa
Formulation
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Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Form
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Liquid
Gene ID
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23028
Uniprot ID
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O60341
Background
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Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes.
Research Area
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Epigenetics and Nuclear Signaling
Synonyms
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KDM1A; AOF2; KDM1; KIAA0601; LSD1; Lysine-specific histone demethylase 1A; BRAF35-HDAC complex protein BHC110; Flavin-containing amine oxidase domain-containing protein 2