Anti-JAK2(R683S Mutant) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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JAK2, JTK10, THCYT3
Host
Storage
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Store at -20°C. Avoid repeated freezing and thawing
Clonality
Clone Number
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7U8-V8-S5
Isotype
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IgG
Reactivity
Application
Application Details
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ELISA: 1/1000-1/2000 WB: 1/500-1/1000 IHC-P: 1/50-1/100
Immunogen
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A synthetic peptide from the internal region of JAK2 which includes the mutation of R683S, human origin.
Formulation
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PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
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Liquid
Uniprot ID
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Background
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JAK2 is a non-receptor tyrosine kinase. It is a number of the Janus kinase family and has been implicated in ssignaling by members of the type II cytokine receptor family, the GM-CSF receptor family, the gp130 receptor family, and the single chain receptors. JAK2 orthologs have been identified in all mammals for which complete genome genome data are available. Mutations of JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders.
Research Area
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Cell Biology
Synonyms
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JAK2, JTK10, THCYT3