Anti-IRF8 Rabbit Polyclonal Antibody
Product Information
Downloads & Supports
Target
-
IRF8
Host
Storage
-
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
-
-
Isotype
-
IgG
Reactivity
Application
Application Details
-
WB: 1/500-1/1000
Immunogen
-
Fusion protein of human IRF8
Molecular Weight
-
Calculated MW: 48 kDa; Observed MW: 48 kDa
Formulation
-
pH 7.4 PBS, 0.05% NaN3, 40% Glycerol
Form
-
Liquid
Gene ID
-
3394
Uniprot ID
-
Q02556
Background
-
Plays a role as a transcriptional activator or repressor (PubMed:25122610). Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8+ dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes .
Research Area
-
Epigenetics and Nuclear Signaling
Synonyms
-
ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP