Anti-IPO4 Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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IPO4
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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6K5-J9-A5
Isotype
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IgG1/Kappa
Reactivity
Application
Application Details
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WB：1/500-1/1000
Immunogen
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Peptide
Molecular Weight
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Calculated MW: 119 kDa; Observed MW:130 kDa
Formulation
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Liquid in PBS, Glycerol and BSA
Form
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Liquid
Gene ID
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79711
Uniprot ID
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Q8TEX9
Background
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Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Research Area
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Signal Transduction
Synonyms
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Imp4b, RanBP4, IMP4B, RANBP4