Anti-Insulin Degrading Enzyme Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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IDE
Host
Storage
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Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Clonality
Clone Number
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R04-4E8
Isotype
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IgG
Reactivity
Application
Application Details
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WB: 1/500-1/1000 IF: 1/50-1/200
Immunogen
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A synthetic peptide of human Insulin degrading enzyme/IDE
Molecular Weight
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Calculated MW: 118 kDa; Observed MW: 118 kDa
Formulation
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50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Form
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Liquid
Gene ID
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3416
Uniprot ID
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P14735
Background
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This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid.
Research Area
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Neuroscience
Synonyms
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INSULYSIN; Insulin degrading enzyme; IDE