Anti-IL-6R Rabbit Monoclonal Antibody
Product Information
Downloads & Supports
Target
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IL6R
Host
Storage
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Store at -20°C to -80°C for 12 months in lyophilized form.
Clonality
Clone Number
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R07-9D-8
Isotype
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IgG
Reactivity
Application
Application Details
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FC: 1/50-1/100 ELISA: 1/10000
Immunogen
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Recombinant human IL6R protein
Molecular Weight
-
-
Formulation
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Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Form
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Lyophilized
Gene ID
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3570
Uniprot ID
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P08887
Background
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This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
Research Area
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Immunology
Synonyms
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CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ