Anti-IDH2(R172G Mutant) Mouse Monoclonal Antibody
Product Information
Downloads & Supports
Target
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IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH
Host
Storage
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Store at -20°C. Avoid repeated freezing and thawing
Clonality
Clone Number
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2D9-D6-Y9
Isotype
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IgG
Reactivity
Application
Application Details
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ELISA: 1/1000-1/5000,WB: 1/100-1/1000,ICC/IF: 1/50-1/100,IHC-P: 1/50-1/100
Immunogen
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A synthetic peptide from the internal region of IDH2 which includes the mutation of R172G, human origin.
Formulation
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PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 50% glycerol
Form
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Liquid
Uniprot ID
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Background
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Isocitrate dehydrogenase (IDH) catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. The isocitrate and isopropylmalate dehydrogenases family has three members, IDH1, IDH2 and IDH3. IDH2 plays a role in intermediary metabolism and energy production. Defects in IDH2 are the cause of D-2-hydroxyglutaric aciduria type 2 (D2HGA2). Somatic mosaic mutations of this protein have also been found associated to Ollier disease and Maffucci syndrome, and R172G IDH2 mutations do exist in diffusely infiltrative gliomas.
Research Area
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Signal Transduction
Synonyms
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IDH2, D2HGA2, ICD-M, IDH, IDHM, IDP, IDPM, mNADP-IDH